Nowadays, there is much interest in using microorganism cell factories to produce natural products, which include metabolites, proteins, fuels, drugs, or food. TWBIO has intellectual properties of special probiotics strains and the know-how formula of high-value products production. TWBIO also has extensive experiences in the scaling-up product production by fermentation, once the perfect cell factories were designed. The following patented and proprietary technologies are employed to develop a sustainable bio-factory and state of the art fermentation and downstream process. The prototype of commercialized astaxanthin products, CaroRED and CaroFarm, is in the current TWBIO pipeline.